Search results for " autologous bone tissue regeneration"

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Growth and Osteogenic Differentiation of Discarded Gingiva-Derived Mesenchymal Stem Cells on a Commercial Scaffold

2020

Background In periodontal patients with jawbone resorption, the autologous bone graft is considered a "gold standard" procedure for the placing of dental prosthesis; however, this procedure is a costly intervention and poses the risk of clinical complications. Thanks to the use of adult mesenchymal stem cells, smart biomaterials, and active biomolecules, regenerative medicine and bone tissue engineering represent a valid alternative to the traditional procedures. Aims In the past, mesenchymal stem cells isolated from periodontally compromised gingiva were considered a biological waste and discarded during surgical procedures. This study aims to test the osteoconductive activity of FISIOGRAF…

0301 basic medicinePathologymedicine.medical_specialtyScaffoldperiodontal diseaseMatriderm®waste gingival tissueoral MSCsperiodontally compromised GMSCsRegenerative medicineBone resorptionSettore MED/13 - EndocrinologiaCell and Developmental Biology03 medical and health sciences0302 clinical medicineSettore MED/28 - Malattie OdontostomatologicheSettore BIO/13 - Biologia ApplicataBiopsymedicineFISIOGRAFT Bone Granular®Viability assaylcsh:QH301-705.5Original Researchautologous bone tissue regenerationmedicine.diagnostic_testCell growthbusiness.industryMesenchymal stem cellCell Biologyperiodontal disease bone resorption waste gingival tissue oral MSCs periodontally compromised GMSCs FISIOGRAFT Bone Granular R Matriderm R autologous bone tissue regenerationResorption030104 developmental biologylcsh:Biology (General)030220 oncology & carcinogenesisbusinessbone resorptionDevelopmental Biology
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In vitro and in vivo investigations of osteogenic differentiation ability of dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSC…

2020

Thanks to the use of human mesenchymal stem cells (hMSCs), smart biomaterials and active biomolecules, Regenerative Medicine (RM) and Bone Tissue Engineering (BTE) can restore structure and function of injured tissues. Among the different sources of hMSCs, the oro-facial hMSCs have promising in vitro and in vivo regeneration potential; in particular, dental pulp and gingiva are valuable sources of autologous hMSCs. The aim of this PhD thesis is testing the in vitro and in vivo bone regeneration ability of hMSCs isolated from dental pulp and inflamed gingiva of periodontally-compromised teeth, up to now considered biological waste tissues and discarded during surgical procedures, on two comm…

Periodontitis bone resorption oral MSCs DPSCs GMSCs waste biological tissues periodontally-compromised teeth FISIOGRAFT Bone Granular® Matriderm® autologous bone tissue regenerationSettore MED/28 - Malattie Odontostomatologiche
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